Assay Detail
Binding
CHEMBL933818
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Activation of SIRT2 by mass spectrometry assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.43 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257991 | — | — | 1 | 4.43 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL403308 | — | — | 1 | - |
| CHEMBL254156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257991 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL165 | RESVERATROL | EC50 | > | 300000.0 | nM | - |
| CHEMBL403308 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL254156 | — | EC50 | > | 300000.0 | nM | - |