Assay Detail
Binding
CHEMBL933897
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Inhibition of Aeromonas hydrophila beta lactamase CphA N116H-N220G mutant by competitive inhibition assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aeromonas hydrophila |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.72 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72628 | 2-PICOLINIC ACID | — | 1 | 4.89 |
| CHEMBL316034 | — | — | 1 | 4.55 |
| CHEMBL286204 | QUINOLINIC ACID | — | 1 | - |
| CHEMBL261326 | — | — | 1 | - |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72628 | 2-PICOLINIC ACID | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL316034 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL286204 | QUINOLINIC ACID | Ki | - | — | - | |
| CHEMBL261326 | — | Ki | - | — | - | |
| CHEMBL88972 | PYRIDINE-2,5-DICARBOXYLIC ACID | Ki | - | — | - |