Compound Detail
CHEMBL286204
QUINOLINIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL286204 |
| Name | QUINOLINIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
3
Targets
6
Activities
4
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
167.1
MW (Da)
0.48
ALogP
3
HBA
2
HBD
87.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.0
Kd 2 meas. best 7.37
EC50 1 meas.
Ki 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Advanced glycosylation end product-specific receptor CHEMBL2176846 | Kd | 7.37 | 7.37 | 43.0 | 1 |
| Advanced glycosylation end product-specific receptor CHEMBL2176847 | Kd | 7.37 | 7.37 | 43.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Advanced glycosylation end product-specific receptor | Kd | = | 43.0 | nM | 7.37 | Binding affinity to Wistar rat His-tagged RAGE domain VC1 expressed in Escherich... | 28482155 |
| Advanced glycosylation end product-specific receptor | Kd | = | 43.0 | nM | 7.37 | Binding affinity to human His-tagged RAGE domain VC1 expressed in Escherichia co... | 28482155 |
| Glutamate NMDA receptor | IC50 | = | 100000.0 | nM | 4.0 | Compound was evaluated for its ability to displace [3H]Glu/[3H]-AP5 from rat bra... | 1533422 |
Literature References
Data from ChEMBL 36 via Core Engine