Assay Detail
ADMET
CHEMBL934016
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Cytotoxicity against PAT active CHO cells after 48 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.96 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558186 | — | — | 1 | 7.35 |
| CHEMBL557403 | — | — | 1 | 7.13 |
| CHEMBL541654 | — | — | 1 | 6.92 |
| CHEMBL540552 | — | — | 1 | 6.35 |
| CHEMBL540336 | — | — | 1 | 6.22 |
| CHEMBL558390 | — | — | 1 | 5.11 |
| CHEMBL3216421 | — | — | 1 | 4.54 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 4.07 |
| CHEMBL537020 | — | — | 1 | - |
| CHEMBL557794 | — | — | 1 | - |
| CHEMBL536774 | — | — | 1 | - |
| CHEMBL536770 | — | — | 1 | - |
| CHEMBL542262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558186 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL557403 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL541654 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL540552 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL540336 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL558390 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3216421 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL537020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL557794 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL536774 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL536770 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL542262 | — | IC50 | > | 1000000.0 | nM | - |