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Assay Detail

CHEMBL934058

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Functional
Antiproliferative activity against human MIA PaCa cells after 96 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PaCa
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.
Grillet F, Baumlová B, Prévost G, Constant JF, Chaumeron S, Bigg DC, Greene AE, Kanazawa A.
Bioorg Med Chem Lett (2008) 18 : 2143 -2146
PubMed 18276141 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.09 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL837 7-ETHYL-10-HYDROXYCAMPTOTHECIN 2.0 1 8.22
CHEMBL257522 1 6.09
CHEMBL257710 1 6.09
CHEMBL270850 1 6.00
CHEMBL205175 1 6.00
CHEMBL402996 1 5.94
CHEMBL412058 1 5.87
CHEMBL257711 1 5.85
CHEMBL269796 1 5.82
CHEMBL401558 1 5.77
CHEMBL257712 1 5.74
CHEMBL270848 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL837 7-ETHYL-10-HYDROXYCAMPTOTHECIN IC50 = 6.0 nM 8.22
CHEMBL257522 IC50 = 810.0 nM 6.09
CHEMBL257710 IC50 = 810.0 nM 6.09
CHEMBL270850 IC50 = 1010.0 nM 6.00
CHEMBL205175 IC50 = 1010.0 nM 6.00
CHEMBL402996 IC50 = 1140.0 nM 5.94
CHEMBL412058 IC50 = 1350.0 nM 5.87
CHEMBL257711 IC50 = 1400.0 nM 5.85
CHEMBL269796 IC50 = 1500.0 nM 5.82
CHEMBL401558 IC50 = 1700.0 nM 5.77
CHEMBL257712 IC50 = 1810.0 nM 5.74
CHEMBL270848 IC50 = 1990.0 nM 5.70