Assay Detail
Functional
CHEMBL934099
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Cytotoxicity against human 1A9 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic simplified tubulysin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.31 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 10.52 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.52 |
| CHEMBL2021530 | — | — | 1 | 6.70 |
| CHEMBL2021534 | — | — | 1 | 6.10 |
| CHEMBL2021533 | — | — | 1 | 4.75 |
| CHEMBL557793 | — | — | 1 | 4.64 |
| CHEMBL553863 | — | — | 1 | 4.62 |
| CHEMBL2021532 | — | — | 1 | 4.60 |
| CHEMBL2021531 | — | — | 1 | - |
| CHEMBL2021535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL61 | PODOFILOX | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2021530 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2021534 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2021533 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL557793 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL553863 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2021532 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2021531 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL2021535 | — | IC50 | > | 33000.0 | nM | - |