Assay Detail
Binding
CHEMBL934144
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Displacement of [3H]PGE2 from EP1 receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel methylene-linked heterocyclic EP1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.46 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234940 | — | — | 1 | 8.60 |
| CHEMBL403330 | — | — | 1 | 8.50 |
| CHEMBL209800 | — | — | 1 | 8.30 |
| CHEMBL272793 | — | — | 1 | 8.20 |
| CHEMBL213221 | — | — | 1 | 8.20 |
| CHEMBL255652 | — | — | 1 | 8.20 |
| CHEMBL377852 | — | — | 1 | 8.10 |
| CHEMBL255009 | — | — | 1 | 8.10 |
| CHEMBL404525 | — | — | 1 | 8.00 |
| CHEMBL270208 | — | — | 1 | 8.00 |
| CHEMBL407175 | — | — | 1 | 8.00 |
| CHEMBL207577 | — | — | 1 | 7.90 |
| CHEMBL257464 | — | — | 1 | 7.70 |
| CHEMBL401768 | — | — | 1 | 7.60 |
| CHEMBL258057 | — | — | 1 | 7.60 |
| CHEMBL403329 | — | — | 1 | 7.40 |
| CHEMBL256674 | — | — | 1 | 7.40 |
| CHEMBL408367 | — | — | 1 | 7.30 |
| CHEMBL404760 | — | — | 1 | 7.30 |
| CHEMBL403460 | — | — | 1 | 7.10 |
| CHEMBL270174 | — | — | 1 | 6.80 |
| CHEMBL403459 | — | — | 1 | 6.80 |
| CHEMBL404239 | — | — | 1 | 6.50 |
| CHEMBL535640 | — | — | 1 | 6.50 |
| CHEMBL257846 | — | — | 1 | 6.20 |
| CHEMBL258303 | — | — | 1 | 6.20 |
| CHEMBL270162 | — | — | 1 | 6.20 |
| CHEMBL273145 | — | — | 1 | 6.10 |
| CHEMBL557194 | — | — | 1 | - |
| CHEMBL538095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234940 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL403330 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL209800 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL272793 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL213221 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL255652 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL377852 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL255009 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL404525 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270208 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL407175 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL207577 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL257464 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL401768 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL258057 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL403329 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL256674 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL408367 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL404760 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL403460 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL270174 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL403459 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL404239 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL535640 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL257846 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL258303 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL270162 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL273145 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL557194 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL538095 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL258304 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL270160 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL269940 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL403863 | — | IC50 | < | 1000.0 | nM | - |