Assay Detail
Functional
CHEMBL934225
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Agonist activity at human Vgamma9Vdelta2 receptor expressed in T cells assessed as stimulation of TNFalpha release by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.62 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145233 | — | — | 1 | 9.41 |
| CHEMBL272435 | — | — | 1 | 9.04 |
| CHEMBL143948 | BROMOHYDRIN PYROPHOSPHATE | — | 1 | 7.62 |
| CHEMBL270681 | — | — | 1 | 7.03 |
| CHEMBL429421 | — | — | 1 | 6.60 |
| CHEMBL272213 | — | — | 1 | 6.07 |
| CHEMBL272000 | — | — | 1 | 5.60 |
| CHEMBL408545 | — | — | 1 | 4.10 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | — | 1 | 4.09 |
| CHEMBL270475 | — | — | 1 | - |
| CHEMBL270468 | — | — | 1 | - |
| CHEMBL272214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145233 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL272435 | — | EC50 | = | 0.91 | nM | 9.04 |
| CHEMBL143948 | BROMOHYDRIN PYROPHOSPHATE | EC50 | = | 23.85 | nM | 7.62 |
| CHEMBL270681 | — | EC50 | = | 93.5 | nM | 7.03 |
| CHEMBL429421 | — | EC50 | = | 252.2 | nM | 6.60 |
| CHEMBL272213 | — | EC50 | = | 852.0 | nM | 6.07 |
| CHEMBL272000 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL408545 | — | EC50 | = | 78731.0 | nM | 4.10 |
| CHEMBL356362 | ISOPENTENYLPYROPHOSPHATE | EC50 | = | 81076.0 | nM | 4.09 |
| CHEMBL270475 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL270468 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL272214 | — | EC50 | > | 100000.0 | nM | - |