Assay Detail
Binding
CHEMBL934433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Sirt2 expressed in Escherichia coli BL21 by fluorescent deacetylase assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.25 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270110 | — | — | 1 | 6.00 |
| CHEMBL438203 | — | — | 1 | 5.82 |
| CHEMBL407321 | — | — | 1 | 5.82 |
| CHEMBL273076 | — | — | 1 | 5.70 |
| CHEMBL407517 | — | — | 1 | 5.64 |
| CHEMBL270478 | — | — | 1 | 5.64 |
| CHEMBL407059 | — | — | 1 | 5.51 |
| CHEMBL409006 | — | — | 1 | 5.50 |
| CHEMBL270109 | — | — | 1 | 5.47 |
| CHEMBL261605 | — | — | 1 | 5.47 |
| CHEMBL271536 | — | — | 1 | 5.36 |
| CHEMBL270292 | — | — | 1 | 5.28 |
| CHEMBL270291 | — | — | 1 | 5.27 |
| CHEMBL402446 | — | — | 1 | 5.19 |
| CHEMBL405156 | — | — | 1 | 5.10 |
| CHEMBL429433 | — | — | 1 | 5.01 |
| CHEMBL270075 | — | — | 1 | 5.00 |
| CHEMBL403988 | — | — | 1 | 4.97 |
| CHEMBL270905 | — | — | 1 | 4.71 |
| CHEMBL272461 | — | — | 1 | 4.71 |
| CHEMBL406803 | — | — | 1 | 4.70 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.49 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270110 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL438203 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL407321 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL273076 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL407517 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL270478 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL407059 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL409006 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL270109 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL261605 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL271536 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL270292 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL270291 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL402446 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL405156 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL429433 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL270075 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL403988 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL270905 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL272461 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL406803 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 53000.0 | nM | 4.28 |