Assay Detail
Binding
CHEMBL934449
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Inhibition of mTOR
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.75 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273832 | — | — | 1 | 6.71 |
| CHEMBL271780 | — | — | 1 | 6.60 |
| CHEMBL405230 | — | — | 1 | 6.25 |
| CHEMBL271982 | — | — | 1 | 6.21 |
| CHEMBL271184 | — | — | 1 | 6.16 |
| CHEMBL409671 | — | — | 1 | 6.12 |
| CHEMBL271544 | — | — | 1 | 6.09 |
| CHEMBL272816 | — | — | 1 | 6.09 |
| CHEMBL410637 | — | — | 1 | 6.08 |
| CHEMBL410071 | — | — | 1 | 6.08 |
| CHEMBL411950 | — | — | 1 | 6.08 |
| CHEMBL272898 | — | — | 1 | 6.06 |
| CHEMBL406237 | — | — | 1 | 6.05 |
| CHEMBL271430 | — | — | 1 | 6.02 |
| CHEMBL260313 | — | — | 1 | 6.02 |
| CHEMBL408074 | — | — | 1 | 5.92 |
| CHEMBL271413 | — | — | 1 | 5.92 |
| CHEMBL405258 | — | — | 1 | 5.87 |
| CHEMBL409427 | — | — | 1 | 5.83 |
| CHEMBL429577 | — | — | 1 | 5.83 |
| CHEMBL273038 | — | — | 1 | 5.77 |
| CHEMBL270039 | — | — | 1 | 5.75 |
| CHEMBL409620 | — | — | 1 | 5.73 |
| CHEMBL407215 | — | — | 1 | 5.64 |
| CHEMBL407214 | — | — | 1 | 5.63 |
| CHEMBL270553 | — | — | 1 | 5.61 |
| CHEMBL410643 | — | — | 1 | 5.54 |
| CHEMBL411907 | SONOLISIB | 2.0 | 1 | 5.51 |
| CHEMBL272595 | — | — | 1 | 5.45 |
| CHEMBL272897 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273832 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL271780 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL405230 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL271982 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL271184 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL409671 | — | IC50 | = | 767.0 | nM | 6.12 |
| CHEMBL271544 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL272816 | — | IC50 | = | 816.0 | nM | 6.09 |
| CHEMBL410637 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL410071 | — | IC50 | = | 822.0 | nM | 6.08 |
| CHEMBL411950 | — | IC50 | = | 831.0 | nM | 6.08 |
| CHEMBL272898 | — | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL406237 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL271430 | — | IC50 | = | 961.0 | nM | 6.02 |
| CHEMBL260313 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL408074 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL271413 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL405258 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL409427 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL429577 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL273038 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL270039 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL409620 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL407215 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL407214 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL270553 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL410643 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL411907 | SONOLISIB | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL272595 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL272897 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL271257 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL270746 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL409251 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL272593 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL272281 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL272197 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL271190 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL406655 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL271191 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL272190 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL428873 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL409294 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL410644 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL405157 | — | IC50 | > | 1690.0 | nM | - |
| CHEMBL412076 | — | IC50 | > | 18700.0 | nM | - |