Compound Detail

CHEMBL411907

SONOLISIB

🧪 Phase II

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🧪 Phase II

C=CCN(/C=C1/C(=O)O[C@H](COC)[C@@]2(C)C1=C(O)C(=O)C1=C2[C@H](OC(C)=O)C[C@]2(C)C(=O)CC[C@@H]12)CC=C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL411907
Name	SONOLISIB
Phase	Phase II
Structure Type	MOL
InChI Key	QIUASFSNWYMDFS-NILGECQDSA-N

Known Names

Px-866 Sonolisib

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

525.6

MW (Da)

3.13

ALogP

HBA

HBD

119.4

PSA (Å²)

0.29

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Single Enantiomer

Flags

Natural Product

USAN Stem

-lisib

Extended Properties

Molecular Formula	C29H35NO8
MW	525.60
Aromatic Rings	0
Heavy Atoms	38
NP-Likeness	1.83

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
PI3-kinase class I inhibitor	INHIBITOR	PI3-kinase class I	✓	✓

Indications

Glioblastoma Prostatic Neoplasms, Castration-Resistant Neoplasms Neoplasms

Activity Summary

IC50 7 meas. best 10.0

Kd 2 meas. best 8.15

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Unchecked CHEMBL612545	IC50	10.0	10.0	0.1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130	IC50	8.52	8.52	3.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005	IC50	8.22	7.64	6.0	2
cAMP-dependent protein kinase catalytic subunit gamma CHEMBL2743	Kd	8.15	8.15	7.0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267	IC50	8.05	8.05	9.0	1
Serine/threonine-protein kinase SIK3 CHEMBL6149	Kd	7.96	7.96	11.0	1
LNCaP CHEMBL612518	IC50	6.24	6.24	573.0	1
Serine/threonine-protein kinase mTOR CHEMBL2842	IC50	5.51	5.51	3100.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Unchecked	IC50	=	0.1	nM	10.0	Inhibition of PI3K (unknown origin)	-
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	IC50	=	3.0	nM	8.52	Inhibition of p110 delta (unknown origin)	20729870
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IC50	=	6.0	nM	8.22	Inhibition of p110 alpha (unknown origin)	20729870
cAMP-dependent protein kinase catalytic subunit gamma	Kd	=	7.0	nM	8.15	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	IC50	=	9.0	nM	8.05	Inhibition of p110 gamma (unknown origin)	20729870
Serine/threonine-protein kinase SIK3	Kd	=	11.0	nM	7.96	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase ...	29191878
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IC50	=	88.0	nM	7.06	Inhibition of PI3K expressed in Escherichia coli by microtiter plate-based fluor...	18269228
LNCaP	IC50	=	573.0	nM	6.24	Growth inhibition of human LNCap cells	18269228
Serine/threonine-protein kinase mTOR	IC50	=	3100.0	nM	5.51	Inhibition of mTOR	18269228

Literature References

PubMed	DOI	Target Context	# Activities
29191878	10.1126/science.aan4368	Unchecked	4
29191878	10.1126/science.aan4368	Peroxisomal acyl-coenzyme A oxidase 3	1
20729870	10.1038/aps.2010.150	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	1
29191878	10.1126/science.aan4368	Beta-adrenergic receptor kinase 1	1
29191878	10.1126/science.aan4368	Adenosine kinase	1
29191878	10.1126/science.aan4368	Atypical kinase COQ8A, mitochondrial	1
29191878	10.1126/science.aan4368	AarF domain-containing protein kinase 1	1
29191878	10.1126/science.aan4368	Activin receptor type-2B	1
29191878	10.1126/science.aan4368	Activin receptor type-1B	1
29191878	10.1126/science.aan4368	Activin receptor type-1	1
29191878	10.1126/science.aan4368	Actin-related protein 3	1
18269228	10.1021/jm7012858	Serine/threonine-protein kinase mTOR	1
29191878	10.1126/science.aan4368	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	1
29191878	10.1126/science.aan4368	Acyl-CoA dehydrogenase family member 11	1
29191878	10.1126/science.aan4368	Acyl-CoA dehydrogenase family member 10	1
29191878	10.1126/science.aan4368	Tyrosine-protein kinase ABL2	1
29191878	10.1126/science.aan4368	Tyrosine-protein kinase ABL1	1
29191878	10.1126/science.aan4368	AP2-associated protein kinase 1	1
-	10.1039/C2MD20044A	Unchecked	1
18269228	10.1021/jm7012858	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	1

Data from ChEMBL 36 via Core Engine