Serine/threonine-protein kinase SIK3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9Y2K2. Use UniProt Q9Y2K2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y2K2 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase SIK3
Review this target as Serine/threonine-protein kinase SIK3, mapped to UniProt Q9Y2K2. Sequence length is 1321 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase SIK3 as ChEMBL target CHEMBL6149, mapped to UniProt Q9Y2K2. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Serine/threonine-protein kinase SIK3 is the right protein anchor across sources, using UniProt Q9Y2K2 as the stable mapping.
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| Preferred Name | Serine/threonine-protein kinase SIK3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2K2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase SIK3 |
| UniProt Accession | Q9Y2K2 |
| Component Type | Protein |
| Sequence Length | 1321 aa |
Serine/threonine-protein kinase SIK3
Review this target as Serine/threonine-protein kinase SIK3, mapped to UniProt Q9Y2K2. Sequence length is 1321 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.34 | Kd | 0.46 | Preclinical |
| CHEMBL5417444 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL5440720 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL388978 | 9.13 | IC50 | 0.74 | Preclinical |
| CHEMBL5431938 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5438171 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5415380 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL5407103 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL5412961 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL5402124 | 8.85 | IC50 | 1.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 119 | 83 | 7.3 |
| cell-based format | 23 | 51 | 7.1 |
| assay format | 16 | 0 | — |
| subcellular format | 11 | 25 | 6.3 |