Skip to main content
Evidence Snapshot

Serine/threonine-protein kinase SIK3

CHEMBL6149 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:16Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6149
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase SIK3 as ChEMBL target CHEMBL6149, mapped to UniProt Q9Y2K2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase SIK3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6149
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9Y2K2
Serine/threonine-protein kinase SIK3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Serine/threonine-protein kinase SIK3 matters

As of 2026-09-13

Serine/threonine-protein kinase SIK3 is reviewed as Serine/threonine-protein kinase SIK3 (UniProt Q9Y2K2); the current evidence base includes 10 approved drugs, 631 compounds, and 169 assays, with lead potency reaching pChEMBL 9.3.

Protein context
Serine/threonine-protein kinase SIK3

Serine/threonine-protein kinase SIK3 Sequence length is 1321 aa.

Review this target as Serine/threonine-protein kinase SIK3, mapped to UniProt Q9Y2K2. Sequence length is 1321 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9Y2K2 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 10 approved drugs, 631 compounds, and 169 assays for this target. The dominant activity type is KD. CHEMBL388978 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL388978 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine
10 approved pChEMBL 9.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Serine/threonine-protein kinase SIK3 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9Y2K2, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

631
Total Compounds
169
Total Assays
10
Approved Drugs
IC50: 149.0, KD: 328.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL388978
 9.3 Kd —
No preferred name
CHEMBL5417444
 9.2 IC50 —
No preferred name
CHEMBL5440720
 9.2 IC50 —
No preferred name
CHEMBL388978
 9.1 IC50 —
No preferred name
CHEMBL5431938
 9.0 IC50 —

Approved Drugs

Structure Compound First Approval
MOMELOTINIB
CHEMBL1078178
 2023
MIDOSTAURIN
CHEMBL608533
 2017
BOSUTINIB
CHEMBL288441
 2012
DASATINIB
CHEMBL5416410
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:16Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6149