Assay Detail
Binding
CHEMBL5654100
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Inhibition of p110 alpha (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.04 | 9.00 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 9.00 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 8.52 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.40 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 8.30 |
| CHEMBL411907 | SONOLISIB | 2.0 | 1 | 8.22 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.80 |
| CHEMBL3349370 | — | — | 1 | 7.41 |
| CHEMBL3360203 | PILARALISIB | 2.0 | 1 | 7.41 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 7.28 |
| CHEMBL1213082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL411907 | SONOLISIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3349370 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3360203 | PILARALISIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1213082 | — | IC50 | > | 100000.0 | nM | - |