Assay Detail
Functional
CHEMBL934508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vascular activity in KPSS precontracted Sprague-Dawley rat thoracic aorta assessed as endothelium dependent relaxation
36
Total Activities
18
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 18 | - | - |
| EC50 | 14 | 5.17 | 5.60 |
| Log EC50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272260 | — | — | 2 | 5.60 |
| CHEMBL242172 | — | — | 2 | 5.49 |
| CHEMBL272247 | — | — | 2 | 5.36 |
| CHEMBL271321 | — | — | 2 | 5.35 |
| CHEMBL405585 | — | — | 2 | 5.33 |
| CHEMBL272682 | — | — | 2 | 5.33 |
| CHEMBL122701 | — | — | 2 | 5.30 |
| CHEMBL272006 | — | — | 2 | 5.17 |
| CHEMBL272005 | — | — | 2 | 5.15 |
| CHEMBL294009 | FLAVONOL | — | 2 | 5.12 |
| CHEMBL270935 | — | — | 2 | 5.09 |
| CHEMBL270353 | — | — | 2 | 4.78 |
| CHEMBL439080 | — | — | 2 | 4.13 |
| CHEMBL270534 | — | — | 2 | - |
| CHEMBL272680 | — | — | 2 | - |
| CHEMBL273103 | — | — | 2 | - |
| CHEMBL270753 | — | — | 2 | - |
| CHEMBL406834 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272260 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL242172 | — | EC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL272247 | — | EC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL271321 | — | EC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL405585 | — | EC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL272682 | — | EC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL122701 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL272006 | — | EC50 | = | 6760.83 | nM | 5.17 |
| CHEMBL272005 | — | EC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL294009 | FLAVONOL | EC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL270935 | — | EC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL270353 | — | EC50 | = | 16595.87 | nM | 4.78 |
| CHEMBL439080 | — | EC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL294009 | FLAVONOL | Activity | = | 91.0 | % | - |
| CHEMBL405585 | — | Activity | = | 38.0 | % | - |
| CHEMBL272247 | — | Activity | = | 98.0 | % | - |
| CHEMBL270353 | — | Activity | = | 77.0 | % | - |
| CHEMBL272260 | — | Activity | = | 100.0 | % | - |
| CHEMBL271321 | — | Activity | = | 98.0 | % | - |
| CHEMBL122701 | — | Activity | = | 102.0 | % | - |
| CHEMBL439080 | — | Activity | = | 37.0 | % | - |
| CHEMBL270534 | — | EC50 | = | 114815.36 | nM | - |
| CHEMBL270534 | — | Activity | = | 23.0 | % | - |
| CHEMBL272006 | — | Activity | = | 53.0 | % | - |
| CHEMBL272005 | — | Activity | = | 79.0 | % | - |
| CHEMBL242172 | — | Activity | = | 98.0 | % | - |
| CHEMBL272682 | — | Activity | = | 99.0 | % | - |
| CHEMBL272680 | — | Log EC50 | - | — | - | |
| CHEMBL406834 | — | Activity | = | 16.0 | % | - |
| CHEMBL272680 | — | Activity | = | 10.0 | % | - |
| CHEMBL273103 | — | Log EC50 | - | — | - | |
| CHEMBL273103 | — | Activity | = | 13.0 | % | - |
| CHEMBL270753 | — | Log EC50 | - | — | - | |
| CHEMBL270753 | — | Activity | = | 6.0 | % | - |
| CHEMBL406834 | — | Log EC50 | - | — | - | |
| CHEMBL270935 | — | Activity | = | 37.0 | % | - |