Assay Detail
Functional
CHEMBL934514
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Vasorelaxant activity against KCl-induced contraction in endothelium-intact Sprague-Dawley rat thoracic aorta
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.25 | 5.32 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271321 | — | — | 2 | 5.32 |
| CHEMBL272682 | — | — | 2 | 5.29 |
| CHEMBL122701 | — | — | 2 | 5.26 |
| CHEMBL272005 | — | — | 2 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271321 | — | EC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL272682 | — | EC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL122701 | — | EC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL272005 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL122701 | — | Activity | = | 100.0 | % | - |
| CHEMBL271321 | — | Activity | = | 100.0 | % | - |
| CHEMBL272005 | — | Activity | = | 87.0 | % | - |
| CHEMBL272682 | — | Activity | = | 95.0 | % | - |