Assay Detail
Functional
CHEMBL934515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasorelaxant activity against KCl-induced contraction in endothelium-denuded Sprague-Dawley rat thoracic aorta
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.19 | 5.26 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272682 | — | — | 2 | 5.26 |
| CHEMBL271321 | — | — | 2 | 5.25 |
| CHEMBL122701 | — | — | 2 | 5.20 |
| CHEMBL272005 | — | — | 2 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272682 | — | EC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL271321 | — | EC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL122701 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL272005 | — | EC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL122701 | — | Activity | = | 100.0 | % | - |
| CHEMBL271321 | — | Activity | = | 93.0 | % | - |
| CHEMBL272005 | — | Activity | = | 86.0 | % | - |
| CHEMBL272682 | — | Activity | = | 92.0 | % | - |