Assay Detail
Functional
CHEMBL934516
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Effect on acetylcholine-induced vasorelaxation in pyrogallol exposed Sprague-Dawley rat thoracic aorta
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.88 | 7.19 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122701 | — | — | 2 | 7.19 |
| CHEMBL271321 | — | — | 2 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122701 | — | EC50 | = | 64.57 | nM | 7.19 |
| CHEMBL271321 | — | EC50 | = | 275.42 | nM | 6.56 |
| CHEMBL122701 | — | Activity | = | 81.0 | % | - |
| CHEMBL271321 | — | Activity | = | 42.0 | % | - |