Assay Detail
Binding
CHEMBL934600
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Inhibition of iNOS
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.88 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112866 | — | — | 1 | 7.28 |
| CHEMBL170580 | — | — | 1 | 7.17 |
| CHEMBL112246 | — | — | 1 | 7.05 |
| CHEMBL170176 | — | — | 1 | 6.52 |
| CHEMBL62077 | — | — | 1 | 5.96 |
| CHEMBL409050 | — | — | 1 | 5.92 |
| CHEMBL260277 | — | — | 1 | 5.92 |
| CHEMBL85823 | — | — | 1 | 5.85 |
| CHEMBL174481 | — | — | 1 | 5.60 |
| CHEMBL360616 | — | — | 1 | 5.47 |
| CHEMBL292099 | — | — | 1 | 5.24 |
| CHEMBL355856 | — | — | 1 | 5.01 |
| CHEMBL112247 | — | — | 1 | 4.89 |
| CHEMBL354899 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112866 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL170580 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL112246 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL170176 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL62077 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL409050 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL260277 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL85823 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL174481 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL360616 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL292099 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL355856 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL112247 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL354899 | — | IC50 | = | 32000.0 | nM | 4.50 |