Assay Detail
Binding
CHEMBL934602
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Inhibition of estrogen receptor beta
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.39 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187105 | — | — | 1 | 9.00 |
| CHEMBL187311 | — | — | 1 | 9.00 |
| CHEMBL185918 | — | — | 1 | 8.30 |
| CHEMBL379889 | — | — | 1 | 7.10 |
| CHEMBL362476 | — | — | 1 | 5.96 |
| CHEMBL261781 | — | — | 1 | 5.92 |
| CHEMBL258553 | — | — | 1 | 5.75 |
| CHEMBL195058 | — | — | 1 | 5.70 |
| CHEMBL258509 | — | — | 1 | 5.68 |
| CHEMBL258552 | — | — | 1 | 5.62 |
| CHEMBL261680 | — | — | 1 | 5.54 |
| CHEMBL406630 | — | — | 1 | 5.51 |
| CHEMBL261780 | — | — | 1 | 5.40 |
| CHEMBL179421 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187105 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL187311 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL185918 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL379889 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL362476 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL261781 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL258553 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL195058 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL258509 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL258552 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL261680 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL406630 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL261780 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL179421 | — | IC50 | = | 10000.0 | nM | 5.00 |