Assay Detail
Binding
CHEMBL934611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation
27
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.89 | 8.52 |
| Ki | 1 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259922 | — | — | 2 | 9.70 |
| CHEMBL410136 | — | — | 1 | 8.52 |
| CHEMBL261021 | — | — | 1 | 8.52 |
| CHEMBL409916 | — | — | 1 | 8.40 |
| CHEMBL259007 | — | — | 1 | 8.40 |
| CHEMBL260807 | — | — | 1 | 8.30 |
| CHEMBL429863 | — | — | 1 | 8.22 |
| CHEMBL260134 | — | — | 1 | 8.22 |
| CHEMBL439267 | — | — | 1 | 8.15 |
| CHEMBL258974 | — | — | 1 | 8.10 |
| CHEMBL265710 | — | — | 1 | 8.10 |
| CHEMBL259212 | — | — | 1 | 8.05 |
| CHEMBL409329 | — | — | 1 | 8.05 |
| CHEMBL410668 | — | — | 1 | 8.00 |
| CHEMBL412265 | — | — | 1 | 7.96 |
| CHEMBL258851 | — | — | 1 | 7.92 |
| CHEMBL440406 | — | — | 1 | 7.89 |
| CHEMBL407046 | — | — | 1 | 7.89 |
| CHEMBL412281 | — | — | 1 | 7.85 |
| CHEMBL261075 | — | — | 1 | 7.75 |
| CHEMBL410667 | — | — | 1 | 7.68 |
| CHEMBL409328 | — | — | 1 | 7.62 |
| CHEMBL258653 | — | — | 1 | 7.17 |
| CHEMBL260383 | — | — | 1 | 6.74 |
| CHEMBL261235 | — | — | 1 | 6.62 |
| CHEMBL407047 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259922 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL261021 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL410136 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL259007 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL409916 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL259922 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL260807 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL429863 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL260134 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL439267 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL258974 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL265710 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL259212 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL409329 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL410668 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL412265 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL258851 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL440406 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL407046 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL412281 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL261075 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL410667 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL409328 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL258653 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL260383 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL261235 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL407047 | — | IC50 | = | 253.0 | nM | 6.60 |