Assay Detail
Binding
CHEMBL934691
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Binding affinity to human thrombin
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.63 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142546 | — | — | 1 | 10.00 |
| CHEMBL254353 | — | — | 1 | 9.42 |
| CHEMBL254557 | — | — | 1 | 9.24 |
| CHEMBL254962 | — | — | 1 | 9.19 |
| CHEMBL254759 | — | — | 1 | 9.18 |
| CHEMBL258018 | — | — | 1 | 9.11 |
| CHEMBL402758 | — | — | 1 | 9.10 |
| CHEMBL257543 | — | — | 1 | 8.92 |
| CHEMBL254784 | — | — | 1 | 8.92 |
| CHEMBL401655 | — | — | 1 | 8.89 |
| CHEMBL403359 | — | — | 1 | 8.77 |
| CHEMBL403310 | — | — | 1 | 8.74 |
| CHEMBL404025 | — | — | 1 | 8.64 |
| CHEMBL254786 | — | — | 1 | 8.54 |
| CHEMBL258198 | — | — | 1 | 8.49 |
| CHEMBL121396 | — | — | 1 | 8.40 |
| CHEMBL256941 | — | — | 1 | 8.40 |
| CHEMBL258225 | — | — | 1 | 8.05 |
| CHEMBL254785 | — | — | 1 | 8.00 |
| CHEMBL255916 | — | — | 1 | 7.96 |
| CHEMBL256091 | — | — | 1 | 7.72 |
| CHEMBL250551 | — | — | 1 | 7.48 |
| CHEMBL401842 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142546 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL254353 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL254557 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL254962 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL254759 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL258018 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL402758 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL257543 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL254784 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL401655 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL403359 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL403310 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL404025 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL254786 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL258198 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL121396 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL256941 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL258225 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL254785 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL255916 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL256091 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL250551 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL401842 | — | Ki | = | 47.0 | nM | 7.33 |