Assay Detail
Functional
CHEMBL935474
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Growth inhibition of human KB3-1 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.26 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.96 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.75 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 6.68 |
| CHEMBL408761 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL408761 | — | IC50 | = | 61680.0 | nM | 4.21 |