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Assay Detail

CHEMBL935608

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Functional
Cytotoxicity against human Panc28 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Panc28
Confidence 1 — Organism
Curated By Autocuration

Publication

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.
Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S.
Bioorg Med Chem Lett (2008) 18 : 2633 -2639
PubMed 18359628 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.63 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1162975 1 7.30
CHEMBL260926 1 6.54
CHEMBL259052 1 6.01
CHEMBL261483 1 5.95
CHEMBL258840 1 5.95
CHEMBL261456 1 5.94
CHEMBL412101 1 5.75
CHEMBL258855 1 5.44
CHEMBL260728 1 5.13
CHEMBL263890 1 5.09
CHEMBL406031 1 5.01
CHEMBL260673 METHYL URSOLATE 1 4.98
CHEMBL410906 1 4.89
CHEMBL260014 1 4.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1162975 IC50 = 50.0 nM 7.30
CHEMBL260926 IC50 = 290.0 nM 6.54
CHEMBL259052 IC50 = 970.0 nM 6.01
CHEMBL261483 IC50 = 1130.0 nM 5.95
CHEMBL258840 IC50 = 1130.0 nM 5.95
CHEMBL261456 IC50 = 1140.0 nM 5.94
CHEMBL412101 IC50 = 1800.0 nM 5.75
CHEMBL258855 IC50 = 3660.0 nM 5.44
CHEMBL260728 IC50 = 7320.0 nM 5.13
CHEMBL263890 IC50 = 8140.0 nM 5.09
CHEMBL406031 IC50 = 9750.0 nM 5.01
CHEMBL260673 METHYL URSOLATE IC50 = 10580.0 nM 4.98
CHEMBL410906 IC50 = 12750.0 nM 4.89
CHEMBL260014 IC50 = 13490.0 nM 4.87