Assay Detail
Binding
CHEMBL935615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.55 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 9.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.96 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.87 |
| CHEMBL262628 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL262628 | — | Ki | = | 2650.0 | nM | 5.58 |