Assay Detail
Functional
CHEMBL935692
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Cytotoxicity against human RPMI-8240 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8240 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 10.12 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256099 | — | — | 1 | 10.89 |
| CHEMBL256302 | — | — | 1 | 10.52 |
| CHEMBL255716 | — | — | 1 | 10.48 |
| CHEMBL257360 | — | — | 1 | 10.35 |
| CHEMBL257572 | — | — | 1 | 10.19 |
| CHEMBL428603 | — | — | 1 | 9.68 |
| CHEMBL257361 | — | — | 1 | 9.48 |
| CHEMBL257629 | — | — | 1 | 9.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL71086 | — | — | 1 | - |
| CHEMBL70790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256099 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL256302 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL255716 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL257360 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL257572 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL428603 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL257361 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL257629 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.004 | nM | - |
| CHEMBL71086 | — | IC50 | = | 0.002 | nM | - |
| CHEMBL70790 | — | IC50 | = | 0.002 | nM | - |