Assay Detail
Functional
CHEMBL935693
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Cytotoxicity against human camptothecin-resistant CPT-K5 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CPT-K5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.68 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71086 | — | — | 1 | 9.13 |
| CHEMBL70790 | — | — | 1 | 9.05 |
| CHEMBL256099 | — | — | 1 | 8.89 |
| CHEMBL255716 | — | — | 1 | 8.66 |
| CHEMBL257360 | — | — | 1 | 8.66 |
| CHEMBL257572 | — | — | 1 | 8.24 |
| CHEMBL257361 | — | — | 1 | 8.15 |
| CHEMBL256302 | — | — | 1 | - |
| CHEMBL257629 | — | — | 1 | - |
| CHEMBL428603 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71086 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL70790 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL256099 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL255716 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL257360 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL257572 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL257361 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL256302 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL257629 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL428603 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 10.0 | nM | - |