Assay Detail
Binding
CHEMBL935757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A3 receptor expressed in HEK293 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.49 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 10.06 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.74 |
| CHEMBL27376 | — | — | 1 | 9.10 |
| CHEMBL402574 | — | — | 1 | 9.07 |
| CHEMBL2368455 | — | — | 1 | 9.05 |
| CHEMBL2368367 | — | — | 1 | 8.93 |
| CHEMBL2112161 | — | — | 1 | 8.92 |
| CHEMBL175543 | — | — | 1 | 8.83 |
| CHEMBL255907 | — | — | 1 | 8.82 |
| CHEMBL2368366 | — | — | 1 | 8.78 |
| CHEMBL2112157 | — | — | 1 | 8.76 |
| CHEMBL2112162 | — | — | 1 | 8.71 |
| CHEMBL2112163 | — | — | 1 | 8.55 |
| CHEMBL257405 | — | — | 1 | 8.35 |
| CHEMBL257573 | — | — | 1 | 8.33 |
| CHEMBL436649 | — | — | 1 | 8.33 |
| CHEMBL258421 | — | — | 1 | 8.22 |
| CHEMBL257785 | — | — | 1 | 8.07 |
| CHEMBL256312 | — | — | 1 | 7.92 |
| CHEMBL256520 | — | — | 1 | 7.84 |
| CHEMBL257833 | — | — | 1 | 7.61 |
| CHEMBL283057 | — | — | 1 | 7.31 |
| CHEMBL402607 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 0.087 | nM | 10.06 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL27376 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL402574 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL2368455 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2368367 | — | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL2112161 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL175543 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL255907 | — | Ki | = | 1.51 | nM | 8.82 |
| CHEMBL2368366 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL2112157 | — | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL2112162 | — | Ki | = | 1.94 | nM | 8.71 |
| CHEMBL2112163 | — | Ki | = | 2.79 | nM | 8.55 |
| CHEMBL257405 | — | Ki | = | 4.46 | nM | 8.35 |
| CHEMBL257573 | — | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL436649 | — | Ki | = | 4.65 | nM | 8.33 |
| CHEMBL258421 | — | Ki | = | 6.06 | nM | 8.22 |
| CHEMBL257785 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL256312 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL256520 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL257833 | — | Ki | = | 24.4 | nM | 7.61 |
| CHEMBL283057 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL402607 | — | Ki | = | 877.0 | nM | 6.06 |