Assay Detail
Binding
CHEMBL935759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radioligand from human adenosine A2A receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.67 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 7.03 |
| CHEMBL27376 | — | — | 1 | 6.11 |
| CHEMBL2368455 | — | — | 1 | 5.89 |
| CHEMBL2368366 | — | — | 1 | 5.80 |
| CHEMBL175543 | — | — | 1 | 5.64 |
| CHEMBL2112163 | — | — | 1 | 5.32 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 5.27 |
| CHEMBL2112161 | — | — | 1 | 5.00 |
| CHEMBL2112157 | — | — | 1 | 5.00 |
| CHEMBL2368367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 93.1 | nM | 7.03 |
| CHEMBL27376 | — | Ki | = | 784.0 | nM | 6.11 |
| CHEMBL2368455 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2368366 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL175543 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL2112163 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL2112161 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL2112157 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL2368367 | — | Ki | > | 10000.0 | nM | - |