Assay Detail
Functional
CHEMBL935830
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Antiviral activity against nelfinavir-resistant HIV1 in MT4 cells assessed as inhibition of p24 Gag protein expression by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.64 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178593 | — | — | 1 | 8.62 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.48 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.68 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.62 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.62 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.29 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.22 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 6.57 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178593 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1323 | DARUNAVIR | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL163 | RITONAVIR | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL584 | NELFINAVIR | EC50 | > | 1000.0 | nM | - |