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Assay Detail

CHEMBL936123

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of synthetic amyloid beta-42 oligomerization by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
Necula M, Kayed R, Milton S, Glabe CG.
J Biol Chem (2007) 282 : 10311 -10324
PubMed 17284452 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.31 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261368 AZURE C 1 7.05
CHEMBL259143 BASIC BLUE 41 1 6.92
CHEMBL261772 MECLOCYCLINE SULFOSALICYLATE 4.0 1 6.60
CHEMBL537899 1 6.08
CHEMBL1237046 ROLITETRACYCLINE 2.0 1 5.73
CHEMBL296966 CHICAGO SKY BLUE SODIUM 1 5.59
CHEMBL13859 1 5.21
CHEMBL1563 DAUNORUBICIN HYDROCHLORIDE 4.0 1 5.13
CHEMBL5314343 1 5.11
CHEMBL429694 CONGO RED -1.0 1 5.00
CHEMBL52347 1,2-NAPHTHOQUINONE 1 4.94
CHEMBL52 NORDIHYDROGUAIARETIC ACID 1 4.84
CHEMBL5219790 CETRIMIDE 2.0 1 4.80
CHEMBL375781 NEOCUPROINE 1 4.76
CHEMBL1093419 LACMOID 1 4.59
CHEMBL567 PERPHENAZINE 4.0 1 4.58
CHEMBL437765 RIFAMYCIN 4.0 1 4.50
CHEMBL43612 JUGLONE 1 4.17
CHEMBL1379 TETRAHYDROTHIOPHENE 1 -
CHEMBL124241 2,2'-DIHYDROXYBENZPHENONE 1 -
CHEMBL2448142 1 -
CHEMBL140 CURCUMIN 3.0 1 -
CHEMBL258921 PHENOLSULFONPHTHALEIN -1.0 1 -
CHEMBL6 INDOMETHACIN 4.0 1 -
CHEMBL3217099 1 -
CHEMBL411675 EOSIN Y SODIUM 1 -
CHEMBL164 MYRICETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261368 AZURE C IC50 = 90.0 nM 7.05
CHEMBL259143 BASIC BLUE 41 IC50 = 120.0 nM 6.92
CHEMBL261772 MECLOCYCLINE SULFOSALICYLATE IC50 = 250.0 nM 6.60
CHEMBL537899 IC50 = 830.0 nM 6.08
CHEMBL1237046 ROLITETRACYCLINE IC50 = 1870.0 nM 5.73
CHEMBL296966 CHICAGO SKY BLUE SODIUM IC50 = 2580.0 nM 5.59
CHEMBL13859 IC50 = 6150.0 nM 5.21
CHEMBL1563 DAUNORUBICIN HYDROCHLORIDE IC50 = 7480.0 nM 5.13
CHEMBL5314343 IC50 = 7690.0 nM 5.11
CHEMBL429694 CONGO RED IC50 = 10000.0 nM 5.00
CHEMBL52347 1,2-NAPHTHOQUINONE IC50 = 11480.0 nM 4.94
CHEMBL52 NORDIHYDROGUAIARETIC ACID IC50 = 14470.0 nM 4.84
CHEMBL5219790 CETRIMIDE IC50 = 15940.0 nM 4.80
CHEMBL375781 NEOCUPROINE IC50 = 17420.0 nM 4.76
CHEMBL1093419 LACMOID IC50 = 25510.0 nM 4.59
CHEMBL567 PERPHENAZINE IC50 = 26060.0 nM 4.58
CHEMBL437765 RIFAMYCIN IC50 = 31640.0 nM 4.50
CHEMBL43612 JUGLONE IC50 = 67600.0 nM 4.17
CHEMBL1379 TETRAHYDROTHIOPHENE IC50 = 122190.0 nM -
CHEMBL124241 2,2'-DIHYDROXYBENZPHENONE IC50 = 244160.0 nM -
CHEMBL2448142 IC50 = 309610.0 nM -
CHEMBL140 CURCUMIN IC50 = 361110.0 nM -
CHEMBL258921 PHENOLSULFONPHTHALEIN IC50 = 426250.0 nM -
CHEMBL6 INDOMETHACIN IC50 = 958000.0 nM -
CHEMBL3217099 IC50 = 2051000.0 nM -
CHEMBL411675 EOSIN Y SODIUM IC50 = 2787000.0 nM -
CHEMBL164 MYRICETIN IC50 = 106870.0 nM -