Compound Detail
CHEMBL261772
MECLOCYCLINE SULFOSALICYLATE 💊 Approved Drug
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💊 Approved Drug
C=C1c2c(Cl)ccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@H]12.O=C(O)c1cc(S(=O)(=O)O)ccc1O
Basic Information
| ChEMBL ID | CHEMBL261772 |
| Name | MECLOCYCLINE SULFOSALICYLATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | FYSVKUUNXYGFLA-CCHMMTNSSA-N |
| Therapeutic | ✓ Yes |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
11
Known Names
2
Indications
1
Mechanisms
Molecular Properties
695.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial 70S ribosome inhibitor | INHIBITOR | Bacterial 70S ribosome | ✓ | ✓ |
Indications
Stomatitis Stomatitis
Activity Summary
IC50 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 250.0 | nM | 6.6 | Inhibition of synthetic amyloid beta-42 oligomerization by ELISA | 17284452 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17284452 | 10.1074/jbc.m608207200 | Unchecked | 4 |
| 19640715 | 10.1016/j.bmcl.2009.07.082 | Unchecked | 2 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
Data from ChEMBL 36 via Core Engine