Assay Detail
Binding
CHEMBL936364
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Binding affinity to ENT1 transporter
115
Total Activities
115
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Equilibrative nucleoside transporter 1 (CHEMBL1997) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 115 | 5.84 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260688 | — | — | 1 | 8.56 |
| CHEMBL259866 | — | — | 1 | 8.32 |
| CHEMBL260570 | — | — | 1 | 8.26 |
| CHEMBL418509 | NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE | — | 1 | 8.07 |
| CHEMBL265689 | — | — | 1 | 7.80 |
| CHEMBL394171 | — | — | 1 | 7.67 |
| CHEMBL260055 | — | — | 1 | 7.66 |
| CHEMBL260166 | — | — | 1 | 7.56 |
| CHEMBL410278 | — | — | 1 | 7.50 |
| CHEMBL260882 | — | — | 1 | 7.48 |
| CHEMBL260645 | — | — | 1 | 7.16 |
| CHEMBL409320 | — | — | 1 | 7.11 |
| CHEMBL408710 | — | — | 1 | 7.09 |
| CHEMBL258627 | — | — | 1 | 7.06 |
| CHEMBL411899 | — | — | 1 | 6.97 |
| CHEMBL410465 | — | — | 1 | 6.91 |
| CHEMBL265930 | — | — | 1 | 6.80 |
| CHEMBL411065 | — | — | 1 | 6.75 |
| CHEMBL263651 | — | — | 1 | 6.75 |
| CHEMBL261793 | — | — | 1 | 6.74 |
| CHEMBL261227 | — | — | 1 | 6.74 |
| CHEMBL259303 | — | — | 1 | 6.70 |
| CHEMBL259759 | — | — | 1 | 6.65 |
| CHEMBL259301 | — | — | 1 | 6.61 |
| CHEMBL411710 | — | — | 1 | 6.60 |
| CHEMBL259189 | — | — | 1 | 6.55 |
| CHEMBL261528 | — | — | 1 | 6.55 |
| CHEMBL427558 | — | — | 1 | 6.51 |
| CHEMBL412113 | — | — | 1 | 6.48 |
| CHEMBL438046 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260688 | — | IC50 | = | 2.754 | nM | 8.56 |
| CHEMBL259866 | — | IC50 | = | 4.786 | nM | 8.32 |
| CHEMBL260570 | — | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL418509 | NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL265689 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL394171 | — | IC50 | = | 21.38 | nM | 7.67 |
| CHEMBL260055 | — | IC50 | = | 21.88 | nM | 7.66 |
| CHEMBL260166 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL410278 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL260882 | — | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL260645 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL409320 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL408710 | — | IC50 | = | 81.28 | nM | 7.09 |
| CHEMBL258627 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL411899 | — | IC50 | = | 107.15 | nM | 6.97 |
| CHEMBL410465 | — | IC50 | = | 123.03 | nM | 6.91 |
| CHEMBL265930 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL263651 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL411065 | — | IC50 | = | 177.83 | nM | 6.75 |
| CHEMBL261793 | — | IC50 | = | 181.97 | nM | 6.74 |
| CHEMBL261227 | — | IC50 | = | 181.97 | nM | 6.74 |
| CHEMBL259303 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL259759 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL259301 | — | IC50 | = | 245.47 | nM | 6.61 |
| CHEMBL411710 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL259189 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL261528 | — | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL427558 | — | IC50 | = | 309.03 | nM | 6.51 |
| CHEMBL438046 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL412113 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL261664 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL261530 | — | IC50 | = | 354.81 | nM | 6.45 |
| CHEMBL411687 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL412078 | — | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL294755 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL261887 | — | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL261327 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL409354 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL408449 | — | IC50 | = | 812.83 | nM | 6.09 |
| CHEMBL410084 | — | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL260497 | — | IC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL265440 | — | IC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL258946 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL410665 | — | IC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL260348 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL259045 | — | IC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL60662 | 6-BENZYLTHIOINOSINE | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL258626 | — | IC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL429511 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL259868 | — | IC50 | = | 2089.3 | nM | 5.68 |