Assay Detail
Binding
CHEMBL936433
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Inhibition of human recombinant IRAP expressed in HEK293 cells
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Beta-homo-amino acid scan of angiotensin IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.58 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408871 | — | — | 1 | 7.69 |
| CHEMBL259019 | — | — | 1 | 7.56 |
| CHEMBL261120 | ANGIOTENSIN IV | — | 1 | 7.25 |
| CHEMBL248592 | — | — | 1 | 7.09 |
| CHEMBL260622 | — | — | 1 | 7.00 |
| CHEMBL408132 | — | — | 1 | 6.96 |
| CHEMBL261417 | — | — | 1 | 6.84 |
| CHEMBL261731 | — | — | 1 | 6.83 |
| CHEMBL261422 | — | — | 1 | 6.78 |
| CHEMBL259382 | — | — | 1 | 6.76 |
| CHEMBL428457 | — | — | 2 | 6.75 |
| CHEMBL403717 | — | — | 1 | 6.20 |
| CHEMBL427940 | — | — | 1 | 5.97 |
| CHEMBL258480 | — | — | 1 | 5.88 |
| CHEMBL258642 | — | — | 1 | 5.67 |
| CHEMBL258452 | — | — | 1 | 5.27 |
| CHEMBL258494 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408871 | — | Ki | = | 20.42 | nM | 7.69 |
| CHEMBL259019 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL261120 | ANGIOTENSIN IV | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL248592 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL260622 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL408132 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL261417 | — | Ki | = | 144.54 | nM | 6.84 |
| CHEMBL261731 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL261422 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL259382 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL428457 | — | Ki | = | 177.83 | nM | 6.75 |
| CHEMBL428457 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL403717 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL427940 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL258480 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL258642 | — | Ki | = | 2137.96 | nM | 5.67 |
| CHEMBL258452 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL258494 | — | Ki | = | 5754.4 | nM | 5.24 |