Assay Detail
Binding
CHEMBL936594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant aldose reductase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.47 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 8.05 |
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 7.52 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.40 |
| CHEMBL273910 | MINALRESTAT | 2.0 | 1 | 7.16 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 6.82 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.04 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.66 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.07 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL273910 | MINALRESTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL82242 | QUERCITRIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL266497 | SORBINIL | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL117 | CHRYSIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL164 | MYRICETIN | IC50 | = | 29000.0 | nM | 4.54 |