Assay Detail
Binding
CHEMBL936640
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Inhibition of COX1
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.19 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | 8.85 |
| CHEMBL275809 | FR-122047 | — | 1 | 7.55 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL409023 | — | — | 1 | 6.10 |
| CHEMBL261265 | — | — | 1 | 5.14 |
| CHEMBL260387 | — | — | 1 | 5.00 |
| CHEMBL279404 | — | — | 1 | 5.00 |
| CHEMBL429148 | — | — | 1 | 4.92 |
| CHEMBL406328 | — | — | 1 | 4.85 |
| CHEMBL261815 | — | — | 1 | 4.80 |
| CHEMBL406515 | — | — | 1 | 4.72 |
| CHEMBL405417 | — | — | 1 | 4.54 |
| CHEMBL261598 | — | — | 1 | 4.52 |
| CHEMBL260566 | — | — | 1 | 4.21 |
| CHEMBL261266 | — | — | 1 | 4.14 |
| CHEMBL259539 | — | — | 1 | 4.06 |
| CHEMBL261485 | — | — | 1 | 4.03 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 4.00 |
| CHEMBL405319 | — | — | 1 | - |
| CHEMBL407577 | — | — | 1 | - |
| CHEMBL261550 | — | — | 1 | - |
| CHEMBL258656 | — | — | 1 | - |
| CHEMBL264163 | — | — | 1 | - |
| CHEMBL260386 | — | — | 1 | - |
| CHEMBL406881 | — | — | 1 | - |
| CHEMBL408808 | — | — | 1 | - |
| CHEMBL442465 | — | — | 1 | - |
| CHEMBL260564 | — | — | 1 | - |
| CHEMBL261321 | — | — | 1 | - |
| CHEMBL261520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL275809 | FR-122047 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL409023 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL261265 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL260387 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL279404 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL429148 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL406328 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL261815 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL406515 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL405417 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL261598 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL260566 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL261266 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL259539 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL261485 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL25 | ASPIRIN | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL405319 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL407577 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL261550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL258656 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL264163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL260386 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL406881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL408808 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL442465 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL260564 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL261321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL261520 | — | IC50 | > | 100000.0 | nM | - |