Assay Detail
Functional
CHEMBL936652
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Cytotoxicity against polyamine transporter deficient CHO-MG cells after 48 hrs by trypan blue staining method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-MG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Designing the polyamine pharmacophore: influence of N-substituents on the transport behavior of polyamine conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.63 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258876 | — | — | 1 | 5.92 |
| CHEMBL260931 | — | — | 1 | 5.16 |
| CHEMBL254003 | — | — | 1 | 4.66 |
| CHEMBL429141 | — | — | 1 | 4.60 |
| CHEMBL419870 | — | — | 1 | 4.48 |
| CHEMBL264968 | — | — | 1 | 4.25 |
| CHEMBL260932 | — | — | 1 | 4.24 |
| CHEMBL258803 | — | — | 1 | 4.22 |
| CHEMBL421884 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258876 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL260931 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL254003 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL429141 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL419870 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL264968 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL260932 | — | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL258803 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL421884 | — | IC50 | = | 66700.0 | nM | 4.18 |