Assay Detail
Functional
CHEMBL936655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against polyamine transporter deficient CHO-MG cells in absence of serum amine oxidase inhibitor aminoguanidine after 48 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-MG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Designing the polyamine pharmacophore: influence of N-substituents on the transport behavior of polyamine conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.56 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421884 | — | — | 1 | 5.15 |
| CHEMBL260932 | — | — | 1 | 4.29 |
| CHEMBL258803 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421884 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL260932 | — | IC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL258803 | — | IC50 | = | 56200.0 | nM | 4.25 |