Assay Detail
Binding
CHEMBL936731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.05 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407909 | — | — | 1 | 8.60 |
| CHEMBL259480 | — | — | 1 | 7.60 |
| CHEMBL261490 | — | — | 1 | 7.47 |
| CHEMBL406585 | — | — | 1 | 7.19 |
| CHEMBL406957 | — | — | 1 | 7.08 |
| CHEMBL261489 | — | — | 1 | 7.05 |
| CHEMBL262862 | — | — | 1 | 7.00 |
| CHEMBL405717 | — | — | 1 | 6.68 |
| CHEMBL405829 | — | — | 1 | 6.52 |
| CHEMBL429689 | — | — | 1 | 6.39 |
| CHEMBL407636 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407909 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL259480 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL261490 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL406585 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL406957 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL261489 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL262862 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL405717 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL405829 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL429689 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL407636 | — | Ki | = | 1000.0 | nM | 6.00 |