Assay Detail
Binding
CHEMBL937419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt1 by cell-based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.07 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262341 | — | — | 1 | 7.80 |
| CHEMBL259967 | — | — | 1 | 7.68 |
| CHEMBL259753 | — | — | 1 | 7.52 |
| CHEMBL259968 | — | — | 1 | 7.51 |
| CHEMBL260670 | — | — | 1 | 7.08 |
| CHEMBL260184 | — | — | 1 | 6.88 |
| CHEMBL259982 | — | — | 1 | 6.83 |
| CHEMBL258844 | — | — | 1 | 6.70 |
| CHEMBL261540 | — | — | 1 | 6.43 |
| CHEMBL258696 | — | — | 1 | 6.28 |
| CHEMBL429703 | — | — | 1 | - |
| CHEMBL407733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262341 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL259967 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL259753 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL259968 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL260670 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL260184 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL259982 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL258844 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL261540 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL258696 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL429703 | — | IC50 | - | — | - | |
| CHEMBL407733 | — | IC50 | - | — | - |