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Assay Detail

CHEMBL937510

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Yersinia pestis KIM6-2082.1+ in presence of iron limiting PMH-D medium
ChEMBL ↗
65
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Yersinia pestis
Confidence 1 — Organism
Curated By Intermediate

Target

Yersinia pestis (CHEMBL614597) ↗
Type ORGANISM
Organism Yersinia pestis

Publication

Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Stirrett KL, Ferreras JA, Jayaprakash V, Sinha BN, Ren T, Quadri LE.
Bioorg Med Chem Lett (2008) 18 : 2662 -2668
PubMed 18394884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC90 33 - -
IC50 32 6.07 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL257780 — — 2 8.00
CHEMBL256128 — — 2 6.70
CHEMBL403496 — — 2 6.40
CHEMBL404040 — — 2 6.40
CHEMBL255894 — — 2 6.30
CHEMBL255241 — — 2 6.22
CHEMBL402040 — — 2 6.22
CHEMBL258034 — — 2 6.16
CHEMBL256351 — — 2 6.16
CHEMBL257397 — — 2 6.16
CHEMBL427902 — — 2 6.16
CHEMBL256080 — — 2 6.10
CHEMBL255435 — — 2 6.05
CHEMBL404731 — — 2 6.00
CHEMBL404041 — — 2 6.00
CHEMBL257608 — — 2 6.00
CHEMBL257574 — — 2 6.00
CHEMBL403142 — — 2 6.00
CHEMBL255008 — — 2 5.70
CHEMBL402821 — — 2 5.70
CHEMBL256079 — — 2 5.70
CHEMBL444374 — — 2 5.70
CHEMBL255234 — — 2 5.52
CHEMBL256309 — — 2 5.52
CHEMBL258440 — — 2 4.77
CHEMBL402834 — — 2 -
CHEMBL256545 — — 2 -
CHEMBL258378 — — 2 -
CHEMBL258166 — — 2 -
CHEMBL402966 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL257780 — IC50 = 10.0 nM 8.00
CHEMBL256128 — IC50 = 200.0 nM 6.70
CHEMBL403496 — IC50 = 400.0 nM 6.40
CHEMBL404040 — IC50 = 400.0 nM 6.40
CHEMBL255894 — IC50 = 500.0 nM 6.30
CHEMBL402040 — IC50 = 600.0 nM 6.22
CHEMBL255241 — IC50 = 600.0 nM 6.22
CHEMBL258034 — IC50 = 700.0 nM 6.16
CHEMBL256351 — IC50 = 700.0 nM 6.16
CHEMBL257397 — IC50 = 700.0 nM 6.16
CHEMBL427902 — IC50 = 700.0 nM 6.16
CHEMBL256080 — IC50 = 800.0 nM 6.10
CHEMBL255435 — IC50 = 900.0 nM 6.05
CHEMBL404041 — IC50 = 1000.0 nM 6.00
CHEMBL257574 — IC50 = 1000.0 nM 6.00
CHEMBL257608 — IC50 = 1000.0 nM 6.00
CHEMBL403142 — IC50 = 1000.0 nM 6.00
CHEMBL404731 — IC50 = 1000.0 nM 6.00
CHEMBL444374 — IC50 = 2000.0 nM 5.70
CHEMBL256079 — IC50 = 2000.0 nM 5.70
CHEMBL255008 — IC50 = 2000.0 nM 5.70
CHEMBL402821 — IC50 = 2000.0 nM 5.70
CHEMBL256309 — IC50 = 3000.0 nM 5.52
CHEMBL255234 — IC50 = 3000.0 nM 5.52
CHEMBL258440 — IC50 = 17000.0 nM 4.77
CHEMBL257574 — MIC90 = 2000.0 nM -
CHEMBL256351 — MIC90 = 2000.0 nM -
CHEMBL256128 — MIC90 = 1000.0 nM -
CHEMBL256545 — MIC90 > 9000.0 nM -
CHEMBL255894 — MIC90 = 1000.0 nM -
CHEMBL403164 — IC50 > 5000.0 nM -
CHEMBL403164 — MIC90 > 5000.0 nM -
CHEMBL256541 — IC50 > 38000.0 nM -
CHEMBL256541 — MIC90 > 38000.0 nM -
CHEMBL402966 — IC50 > 38000.0 nM -
CHEMBL402966 — MIC90 > 38000.0 nM -
CHEMBL258166 — IC50 > 19000.0 nM -
CHEMBL402821 — MIC90 = 5000.0 nM -
CHEMBL257780 — MIC90 > 9000.0 nM -
CHEMBL404731 — MIC90 = 3000.0 nM -
CHEMBL258034 — MIC90 > 19000.0 nM -
CHEMBL256079 — MIC90 = 5000.0 nM -
CHEMBL403496 — MIC90 > 5000.0 nM -
CHEMBL402834 — MIC90 > 19000.0 nM -
CHEMBL256545 — IC50 > 9000.0 nM -
CHEMBL372795 STREPTOMYCIN MIC90 = 200.0 nM -
CHEMBL427902 — MIC90 = 2000.0 nM -
CHEMBL444374 — MIC90 = 6000.0 nM -
CHEMBL402834 — IC50 > 19000.0 nM -
CHEMBL256080 — MIC90 = 2000.0 nM -