Assay Detail
Binding
CHEMBL937576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BCL2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.23 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 6.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.63 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.33 |
| CHEMBL346119 | THEAFLAVIN | — | 1 | 6.16 |
| CHEMBL436605 | ANTIMYCIN A3 | — | 1 | 6.08 |
| CHEMBL253536 | — | — | 1 | 5.91 |
| CHEMBL255690 | — | — | 1 | 5.89 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
| CHEMBL206452 | CATECHIN | — | 1 | - |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL402609 | THEAFLAVIN DIGALLTE | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36327 | EPICATECHIN GALLATE | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | Ki | = | 234.42 | nM | 6.63 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL346119 | THEAFLAVIN | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL436605 | ANTIMYCIN A3 | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL253536 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL255690 | — | Ki | = | 1288.25 | nM | 5.89 |
| CHEMBL376408 | ABT 737 | Ki | <= | 1.0 | nM | - |
| CHEMBL206452 | CATECHIN | Ki | > | 100000.0 | nM | - |
| CHEMBL47386 | EPIGALLOCATECHIN | Ki | > | 100000.0 | nM | - |
| CHEMBL402609 | THEAFLAVIN DIGALLTE | Ki | > | 100000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | Ki | > | 100000.0 | nM | - |