Assay Detail
Binding
CHEMBL937847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from rat 5HT1A receptor expressed in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.79 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.52 |
| CHEMBL482276 | — | — | 1 | 6.82 |
| CHEMBL506721 | — | — | 1 | 6.19 |
| CHEMBL455051 | — | — | 1 | 5.64 |
| CHEMBL481879 | — | — | 1 | - |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | - |
| CHEMBL62 | SCH-23390 | — | 1 | - |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL482276 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL506721 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL455051 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL481879 | — | Ki | - | — | - | |
| CHEMBL267930 | SPIPERONE | Ki | - | — | - | |
| CHEMBL62 | SCH-23390 | Ki | - | — | - | |
| CHEMBL53 | APOMORPHINE | Ki | - | — | - |