Assay Detail
Functional
CHEMBL937973
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Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.70 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444949 | — | — | 1 | 8.05 |
| CHEMBL452138 | — | — | 1 | 8.05 |
| CHEMBL500033 | — | — | 1 | 7.96 |
| CHEMBL509895 | BRUCEANTIN | — | 1 | 7.40 |
| CHEMBL509858 | — | — | 1 | 7.40 |
| CHEMBL463295 | — | — | 1 | 7.40 |
| CHEMBL444177 | QUASSIMARIN | — | 1 | 7.22 |
| CHEMBL450464 | BRUSATOL | — | 1 | 7.16 |
| CHEMBL504648 | — | — | 1 | 7.16 |
| CHEMBL506841 | — | — | 1 | 7.12 |
| CHEMBL486998 | SOULARUBINONE | — | 1 | 7.00 |
| CHEMBL448765 | — | — | 1 | 6.82 |
| CHEMBL501007 | — | — | 1 | 6.72 |
| CHEMBL494560 | — | — | 1 | 6.70 |
| CHEMBL498937 | — | — | 1 | 6.70 |
| CHEMBL519243 | HOLACANTHONE | — | 1 | 6.70 |
| CHEMBL494374 | — | — | 1 | 6.58 |
| CHEMBL521129 | SAMADERIN B | — | 1 | 6.40 |
| CHEMBL507027 | — | — | 1 | 6.40 |
| CHEMBL523681 | GLAUCARUBOLONE | — | 1 | 6.40 |
| CHEMBL1202062 | — | — | 1 | 6.30 |
| CHEMBL458347 | GLAUCARUBINONE | — | 1 | 6.30 |
| CHEMBL493225 | — | — | 1 | 6.30 |
| CHEMBL487903 | — | — | 1 | 6.22 |
| CHEMBL446308 | — | — | 1 | 6.16 |
| CHEMBL487286 | — | — | 1 | 6.00 |
| CHEMBL487698 | — | — | 1 | 6.00 |
| CHEMBL472016 | CHAPARRINONE | — | 1 | 5.92 |
| CHEMBL520562 | — | — | 1 | 5.82 |
| CHEMBL469501 | YADANZIOLIDE C | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444949 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL452138 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL500033 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL509895 | BRUCEANTIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL509858 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL463295 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL444177 | QUASSIMARIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL450464 | BRUSATOL | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL504648 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL506841 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL486998 | SOULARUBINONE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL448765 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL501007 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL519243 | HOLACANTHONE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL498937 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL494560 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL494374 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL521129 | SAMADERIN B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL507027 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL523681 | GLAUCARUBOLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1202062 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL458347 | GLAUCARUBINONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL493225 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL487903 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL446308 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL487286 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL487698 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL472016 | CHAPARRINONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL520562 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL469501 | YADANZIOLIDE C | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL488725 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL480882 | SIMALIKALACTONE D | IC50 | > | 200.0 | nM | - |
| CHEMBL482808 | — | IC50 | > | 3000.0 | nM | - |