Assay Detail
Functional
CHEMBL937974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 6.59 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452138 | — | — | 1 | 8.05 |
| CHEMBL500033 | — | — | 1 | 7.77 |
| CHEMBL444949 | — | — | 1 | 7.72 |
| CHEMBL509895 | BRUCEANTIN | — | 1 | 7.70 |
| CHEMBL509858 | — | — | 1 | 7.60 |
| CHEMBL506841 | — | — | 1 | 7.26 |
| CHEMBL450464 | BRUSATOL | — | 1 | 7.16 |
| CHEMBL444177 | QUASSIMARIN | — | 1 | 7.05 |
| CHEMBL504648 | — | — | 1 | 7.05 |
| CHEMBL501007 | — | — | 1 | 6.89 |
| CHEMBL494374 | — | — | 1 | 6.85 |
| CHEMBL519243 | HOLACANTHONE | — | 1 | 6.70 |
| CHEMBL486998 | SOULARUBINONE | — | 1 | 6.70 |
| CHEMBL507027 | — | — | 1 | 6.52 |
| CHEMBL493225 | — | — | 1 | 6.30 |
| CHEMBL494560 | — | — | 1 | 6.30 |
| CHEMBL448765 | — | — | 1 | 6.30 |
| CHEMBL498937 | — | — | 1 | 6.22 |
| CHEMBL521129 | SAMADERIN B | — | 1 | 6.00 |
| CHEMBL523681 | GLAUCARUBOLONE | — | 1 | 5.89 |
| CHEMBL458347 | GLAUCARUBINONE | — | 1 | 5.75 |
| CHEMBL487903 | — | — | 1 | 5.72 |
| CHEMBL487698 | — | — | 1 | 5.70 |
| CHEMBL472016 | CHAPARRINONE | — | 1 | 5.62 |
| CHEMBL446308 | — | — | 1 | 5.52 |
| CHEMBL469501 | YADANZIOLIDE C | — | 1 | 5.00 |
| CHEMBL480882 | SIMALIKALACTONE D | — | 1 | - |
| CHEMBL1202062 | — | — | 1 | - |
| CHEMBL487286 | — | — | 1 | - |
| CHEMBL520562 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452138 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL500033 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL444949 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL509895 | BRUCEANTIN | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL509858 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL506841 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL450464 | BRUSATOL | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL444177 | QUASSIMARIN | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL504648 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL501007 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL494374 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL519243 | HOLACANTHONE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL486998 | SOULARUBINONE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL507027 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL494560 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL448765 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL493225 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL498937 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL521129 | SAMADERIN B | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL523681 | GLAUCARUBOLONE | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL458347 | GLAUCARUBINONE | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL487903 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL487698 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL472016 | CHAPARRINONE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL446308 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL469501 | YADANZIOLIDE C | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL480882 | SIMALIKALACTONE D | EC50 | > | 200.0 | nM | - |
| CHEMBL1202062 | — | EC50 | > | 1500.0 | nM | - |
| CHEMBL487286 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL520562 | — | EC50 | > | 6000.0 | nM | - |
| CHEMBL488725 | — | EC50 | > | 7000.0 | nM | - |
| CHEMBL482808 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL463295 | — | EC50 | > | 50.0 | nM | - |