Assay Detail
Functional
CHEMBL937987
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Cytotoxicity against human multidrug-resistant SKVLB1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SKVLB1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.76 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396298 | ELACRIDAR | 2.0 | 1 | 5.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.66 |
| CHEMBL445732 | PERVILLEINE A | — | 1 | - |
| CHEMBL508381 | — | — | 1 | - |
| CHEMBL486059 | PERVILLEINE B | — | 1 | - |
| CHEMBL451845 | PERVILLEINE C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396298 | ELACRIDAR | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL445732 | PERVILLEINE A | IC50 | > | 10000.0 | nM | - |
| CHEMBL508381 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL486059 | PERVILLEINE B | IC50 | > | 10000.0 | nM | - |
| CHEMBL451845 | PERVILLEINE C | IC50 | > | 10000.0 | nM | - |