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Assay Detail

CHEMBL938291

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver arginase
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Arginase-1 (CHEMBL1075060)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
Kotthaus J, Schade D, Töpker-Lehmann K, Beitz E, Clement B.
Bioorg Med Chem (2008) 16 : 2305 -2312
PubMed 18083522 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 4.65 4.77
IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL260628 2 4.77
CHEMBL260629 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL260628 Ki = 17100.0 nM 4.77
CHEMBL260629 Ki = 30000.0 nM 4.52
CHEMBL260628 IC50 = 123000.0 nM -