Compound Detail
CHEMBL260628
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL260628 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQOBXIWZIBXWRL-YFKPBYRVSA-N |
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
220.2
MW (Da)
-1.17
ALogP
5
HBA
5
HBD
131.4
PSA (Ų)
0.17
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas.
Ki 1 meas. best 4.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075060 | Ki | 4.77 | 4.77 | 17100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | Ki | = | 17100.0 | nM | 4.77 | Inhibition of bovine liver arginase | 18083522 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18083522 | 10.1016/j.bmc.2007.11.066 | Arginase-1 | 2 |
| 18083522 | 10.1016/j.bmc.2007.11.066 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | 1 |
| 18083522 | 10.1016/j.bmc.2007.11.066 | Nitric oxide synthase 3 | 1 |
| 18083522 | 10.1016/j.bmc.2007.11.066 | Nitric oxide synthase, inducible | 1 |
| 18083522 | 10.1016/j.bmc.2007.11.066 | Nitric oxide synthase 1 | 1 |
Data from ChEMBL 36 via Core Engine