Assay Detail
Functional
CHEMBL938320
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Antiviral activity against Vaccinia virus in HFF cells after 1 hr by plaque reduction assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.04 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214955 | — | — | 1 | 5.34 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.25 |
| CHEMBL382702 | — | — | 1 | 5.16 |
| CHEMBL216289 | — | — | 1 | 5.10 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.96 |
| CHEMBL382253 | — | — | 1 | 4.96 |
| CHEMBL214082 | — | — | 1 | 4.77 |
| CHEMBL443308 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214955 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL788 | IDOXURIDINE | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL382702 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL216289 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL382253 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL214082 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL443308 | — | EC50 | = | 18000.0 | nM | 4.75 |