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Assay Detail

CHEMBL938343

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HL60 cells
ChEMBL ↗
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.
Antimicrob Agents Chemother (2007) 51 : 2164 -2172
PubMed 17371810 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 6.10 6.92
MIC 19 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL263380 — — 2 6.92
CHEMBL404610 — — 2 6.92
CHEMBL264145 — — 2 6.85
CHEMBL56640 — — 2 6.84
CHEMBL258727 — — 2 6.65
CHEMBL264512 — — 2 6.61
CHEMBL260934 — — 2 6.57
CHEMBL405356 — — 2 6.57
CHEMBL258944 — — 2 6.31
CHEMBL259289 — — 2 6.31
CHEMBL227559 — — 2 5.93
CHEMBL92547 — — 2 5.83
CHEMBL258645 — — 2 5.78
CHEMBL328742 — — 2 5.78
CHEMBL258675 — — 2 5.52
CHEMBL329647 — — 2 5.50
CHEMBL166 MELARSOPROL 3.0 2 5.37
CHEMBL90969 — — 2 5.02
CHEMBL264408 — — 2 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL263380 — EC50 = 120.0 nM 6.92
CHEMBL404610 — EC50 = 119.0 nM 6.92
CHEMBL264145 — EC50 = 142.0 nM 6.85
CHEMBL56640 — EC50 = 144.0 nM 6.84
CHEMBL258727 — EC50 = 225.0 nM 6.65
CHEMBL264512 — EC50 = 244.0 nM 6.61
CHEMBL260934 — EC50 = 270.0 nM 6.57
CHEMBL405356 — EC50 = 270.0 nM 6.57
CHEMBL259289 — EC50 = 491.0 nM 6.31
CHEMBL258944 — EC50 = 491.0 nM 6.31
CHEMBL227559 — EC50 = 1180.0 nM 5.93
CHEMBL92547 — EC50 = 1480.0 nM 5.83
CHEMBL328742 — EC50 = 1650.0 nM 5.78
CHEMBL258645 — EC50 = 1650.0 nM 5.78
CHEMBL258675 — EC50 = 3040.0 nM 5.52
CHEMBL329647 — EC50 = 3140.0 nM 5.50
CHEMBL166 MELARSOPROL EC50 = 4270.0 nM 5.37
CHEMBL90969 — EC50 = 9470.0 nM 5.02
CHEMBL264408 — EC50 = 26300.0 nM 4.58
CHEMBL90969 — MIC > 10000.0 nM -
CHEMBL166 MELARSOPROL MIC = 100000.0 nM -
CHEMBL264408 — MIC > 10000.0 nM -
CHEMBL404610 — MIC = 7000.0 nM -
CHEMBL258675 — MIC = 10000.0 nM -
CHEMBL329647 — MIC = 10000.0 nM -
CHEMBL328742 — MIC = 10000.0 nM -
CHEMBL405356 — MIC = 10000.0 nM -
CHEMBL258645 — MIC = 10000.0 nM -
CHEMBL258727 — MIC = 10000.0 nM -
CHEMBL92547 — MIC = 10000.0 nM -
CHEMBL258944 — MIC = 10000.0 nM -
CHEMBL264512 — MIC = 10000.0 nM -
CHEMBL56640 — MIC = 10000.0 nM -
CHEMBL263380 — MIC = 1000.0 nM -
CHEMBL259289 — MIC > 10000.0 nM -
CHEMBL260934 — MIC = 10000.0 nM -
CHEMBL264145 — MIC = 10000.0 nM -
CHEMBL227559 — MIC = 10000.0 nM -